01 May In this module we have been studying excitable tissues.
In this module we have been studying excitable tissues.
Hopefully, you are all familiar with the concept of Na+ and
K+ movement across the plasma membrane affecting
membrane potential and triggering action potentials.
Another important ion that we haven’t discussed
extensively is Cl. This assessment is going to focus on the
importance of Clions
in the central nervous system and
skeletal and smooth muscle.
In the central nervous system, GABA is an important neurotransmitter. Describe how GABA exerts its
physiological effect and how it affects neuronal excitability in the CNS.
Valium is a benzodiazepine that is commonly prescribed to patients with generalised anxiety, panic
disorders and OCD. Unfortunately, it is one of the drugs commonly implicated in accidental suicide,
particularly in combination with alcohol or barbiturate drugs. Physiologically, why is the combination
worse than taking Valium alone?
Chloride ions also play a role in skeletal muscle. What type of channel is responsible for this Clmovement,
where would you expect to find it and what physiological function does it play.
Channelopathies are conditions that affect ion channel function. Describe a channelopathy that
affects the conduction of Cl- in skeletal muscle.
You need to present your answers in a 5 minutes audio visual presentation which is aimed at
undergraduate students who have some basic physiological knowledge.
A percentage of the marks for this presentation will come from the references that you use. Wikipedia
and other websites are not sufficien
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