10 Jun BIOLOGY 1 – What type of mutation causes Sickle cell amemia
Question
1) What type of mutation causes Sickle cell amemia? What type of mutation causes Huntington’s disease?
these diseases?)
2) What is the effect of those mutations on the structure of the protein?
4) Are these mutations present in the DNA, RNA, or both?
5) Are these mutations the result of a mistake in DNA replication or transcription?
6) Which enzyme was most likely to cause these mistakes?
7) The genetic code is read in triplets. What would happen if you add 3 new nucleotides to a gene?
9) What is the heritability pattern of these diseases (dominant, recessive, incomplete dominance, etc)?
10) If the father has the disease but the mother doesn’t have the disease, what are the chances that the offspring will inherit these diseases? (assuming both parents are homozygous, then do it again assuming one parent is homozygous and the other is heterozygous)
11) For your research in these diseases you want to produce these proteins in the lab, using bacteria in Petri dishes. What would be the steps in order to produce these proteins in the lab?
12) Can you copy the gene region in a human chromosome and insert it into a bacterium directly?
13) Given an X percentage of affected individuals, estimate p and q.
14) Given p or q, estimate how many individuals will have a given genotype.
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