10 Jun Define the term genetic variation
uestion
1.
Define the term “genetic variation.”
If a gene or locus has two alleles (A and a) in a population, what are all the possible genotypes?
If the frequency of (A) allele = p, and the frequency of (a) allele is q, what is the frequency of all possible genotypes in this population?
2.
What is the Hardy-Weinberg equilibrium?
In a population, a locus A has two alleles (A) and (a). The frequency f of (A) is f (A) = 0.6; what is the f (a)?
Using these frequencies, calculate the frequencies of all possible genotypes in a population in Hardy-Weinberg equilibrium.
3.
In a population (Z), the frequencies of genotypes of a two allele locus (B and b) are f(BB) = 0.3, f(bb) = 0.6, f (Bb) = 0.1. Calculate the frequencies of both alleles.
Using the allele frequencies calculated in a., calculate the frequencies of all possible genotypes at this locus in a population after one generation of random mating.
Is the population (Z) in part a above in Hardy-Weinberg equilibrium? The population size is 1000.
4.
Describe how you would use the Hardy-Weinberg equilibrium to calculate genotype frequencies of a locus with three alleles.
If the f(D) of an X-linked gene in a population = 0.8, what is the f(d) of the other allele at this locus?
What is the frequency of females’ homozygous for d allele (XdXd)?
What is the frequency of males’ hemizygous for the d allele (XdY)?
5.
Explain why more males present with X-linked recessive diseases. Show your reasoning.
Why must the five assumptions/criteria apply to a population before we can say it is in Hardy-Weinberg equilibrium?
Take any one of these assumptions and explain in detail how it could disrupt the Hardy-Weinberg equilibrium for a particular gene locus.
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