10 Jun BIOLOGY 2200 – Which is true of a drug target
Question
11. Which is true of a drug target?
a. It may be the site of action
b. It may be the site of inhibition
c. A & B
d. None of the above
12. You have sequenced the DNA of a new pathogen and will use computers to interpret this sequences. This is called?
a. Computational Chemistry
b. Bioinformatics
c. Biostatistics
d. Immunology
13. Good choices to design drugs to target in a bacteria would include?
a. Sites / Areas known for growth
b. Sites / Areas known for survival
c. A & B
d. None of the above
14. In creating a drug to kill a pathogen (e.g., bacteria) it is important that the drug:
a. Kill the pathogen
b. Create little harm (or kill) the patient
c. A & B
d. None of the above
15. Sites for “attacking” a pathogen could include?
a. Pathogen’s DNA
b. Pathogen’s Plasma Membrane
c. Pathogen’s cell wall
d. All of the above
16. Which of the following statements are true?
a. Manufactures for drug production need to be certified by the FDA first
b. Each manufacturing process needs to be documented
c. A & B
d. None of the above
17. Which of the following statement are factors affecting the manufacture of bio-drugs?
a. Raw materials utilized in the manufacturing process
b. Color-coding of the samples
c. A & B
d. None of the above
18. Which of the following is true about an ideal drug?
a. It is efficacious (effective)
b. It has very low to no toxicity
c. A & B
d. None of the above
19. Which of the following is a type of IND?
a. Sustained Use
b. Non-conforming
c. A & B
d. None of the above
20. Which of the following are questions to be considered in drug development?
a. Is the drug metabolized and if so, to what?
b. Is the drug cytotoxic or mutagenic?
c. A & B
d. None of the above
21. Which federal agency regulates drug development:
a. FBI
b. DEA
c. FDA
d. Congress
22. Personal medicine includes:
a. Tailoring Drugs to the patient’s genotype
b. Getting to know the patient’s activities
c. A & B
d. None of the above
23. Modern Pharma companies outsource to CRO’s. What part of the drug discovery process do CRO’s handle?
a. Marketing
b. Production
c. Medicinal Chemistry
d. Clinical Trials
24. The human genome project included:
a. Sequencing of the genome
b. Determining the function of all human genes
c. Both A & B
d. None of the above
25. John is accepted into a clinical trial, which are true?
a. He must be given a copy of the informed consent paper
b. He must sign the informed consent paper
c. A & B
d. None of the above
26. Which might cause a drug trial to come to a halt?
a. 10% of the participants die because of the drug
b. The CEO of the drug company is charged with embezzlement
c. A & B
d. None of the above
27. When does a participant in a drug trial receive a physical?
a. Before the trial
b. After the trial
c. A & B
d. None of the above
28. Which phase of the clinical trial normally has the least number of participants?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV
29. Which phase of the clinical trial ONLY looks at side effects?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV
30. Which of the following phases of the clinical trial would include the fewest participants?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV
31. Why are clinical trials performed?
a. To test new drugs to see if they work against disease
b. To meet requirements that all pharma companies create 10 new drugs per year
c. Both A & B
d. None of the above
32. Which is true about informed consent?
a. It must be written at a 10th grade level of English
b. It must be written in at least 10 languages
c. Both A & B
d. None of the above
33. Which phase of a clinical trial occurs after the drug has been released?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV
34. Which is true about toxicity?
a. In ALL cases toxicity seen in a clinical trial causes suspension of the trial
b. If the toxicity compared to the reward of the drug is much less a clinical trial will not be suspended
c. Both A & B
d. None of the above
35. Which phase of the clinical trial ONLY looks at side effects?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV
36. Which is true about informed consent?
a. It must be written at a 10th grade level of English
b. It must be written in at least 10 languages
c. Both A & B
d. None of the above
37. Which “phase” of a clinical trial occurs after the drug has been released?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV
38. Which of the following must be disclosed in informed consent documents?
a. Patient may quit at any time
b. Hourly reimbursement for participation
c. A & B
d. None of the above
39. Which of the following statement are factors affecting the manufacture of bio-drugs?
a. Raw materials utilized in the manufacturing process
b. Color-coding of the samples
c. A & B
d. None of the above
40. Which is not an International Drug Class
a. Hallucinogens
b. Inhalants
c. Sunscreen
d. Dissociative Anesthetics
41. Which is not a Narcotic Analgesic
a. Codein
b. Demerol
c. Oxycontin
d. All are narcotic analgesics
42. Pilot studies in manufacturing:
a. Are not used in drug manufacturing
b. Act as a “test run” for large scale-up
c. A & B
d. None of the above
43. Why is the drug industry so large?
a. People get sick
b. Baby-boomers are getting older
c. A & B
d. None of the above
44. Drug companies and purchase drug targets from Biotech Companies by:
a. Upfront Payment
b. Royalties
c. Equity
d. All of the above
45. Which is true of hiring a CRO
a. The CRO always provides credit ($)
b. The CRO has poor network of sites to find patients
c. A & B
d. None of the Above
46. Which is not an economic classification of a drug?
a. Blockbuster
b. Orphan
c. Epic Fail
d. All are economic classifications
47. When choosing a drug or disease to work on, the pharmaceutical companies take into consideration:
a. Market Potential
b. Competition
c. A & B
d. None of the Above
48. What percentage of Drug Targets are G-protein Coupled Receptors?
a. 26.8
b. 13.0
c. 13.4
d. 46.8
49. Which drugs are central nervous system depressants?
a. Alcohol
b. Aspirin
c. A & B
d. None of the Above
50. Which is an average time-line for the development of a drug?
a. 1 – 3 years
b. 5 – 8 years
c. 10 – 12 years
d. 25 – 30 years
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