11 Jun Given below is part of DNA double helix undergoing
Question
Class activity 6_Spr17 – Exam 2 practice
1) Given below is part of DNA double helix undergoing replication. Label the
following.
a) ORI sequence
b) A replication fork
c) Direction of movement of a fork
d) 5’ and 3’ ends of one Okazaki fragment
e) One Leading strand
f) 5’ and 3’ ends of parent strands
g) replication bubble 2) For the ds DNA given below, write a product of transcription. Label its 5’ and
3’ ends. Label the template strand.
What is the name of the enzyme that would make this product of
transcription in Prokaryotes?
5’-PROMOTER-AGCTTAGGACGGATACC-3’
3’-PROMOTER-TCGAATCCTGCCTATGG-5’ 3) Translate the given mRNA using the genetic code table provided. Indicate N and
C ends.
Wild type:
5’-A-C-A-U-G-C-C-C-A-A-A-A-U-U-G-G-C-A-G-G-U-G-A-A-G-3’ B) Compare the wild type sequence with the two mutants below and name the type
of mutation in each (Silent/missense/nonsense/frameshift) (4 POINTS)
MUT 1:
5’-A-C-A-U-G-C-C-C-U-A-A-A-U-U-G-G-C-A-G-G-U-G-A-A-G-3’
MUT 2:
5’-A-C-A-U-G-C-C-C-A-A-A-A-U-G-G-G-C-A-G-G-U-G-A-A-G-3’ 4) State ONE cellular structure that you would expect to be present in abundance in
each of the following cell. Explain your choice in 1-2 sentences.
1) Muscle cell 2) Macrophage 3) B lymphocyte 5) Leigh’s disease is a rare inherited neurometabolic disorder that affects the central
nervous system. This progressive disorder begins in infants between the ages of
three months and two years. Rarely, it occurs in teenagers and adults. The condition
leads to the inability to effectively produce ATP due to a defective gene for one of the
ATPase enzymes. Leigh’s disease can be caused by deficiencies of an enzyme called
pyruvate dehydrogenase. Symptoms of Leigh’s disease usually progress rapidly. The
earliest signs may be poor sucking ability, and the loss of head control and motor
skills. These symptoms may be accompanied by loss of appetite, vomiting,
irritability, continuous crying, and seizures. As the disorder progresses, symptoms
may also include generalized weakness, lack of muscle tone, and episodes of lactic
acidosis, which can lead to impairment of respiratory and kidney function
(http://www.ninds.nih.gov/disorders/leighsdisease/leighsdisease.htm). A) Based on the information, what cell component do you think could be
defective? B) Briefly explain why you chose this particular organelle or cellular
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