11 Jun MCB 10 PSet 1 – For each of the following 4
Question
MCB 10 Problem Set 1 (15 Points Total) Fa 2016 Questions 1 to 4 (4 Points): For each of the following 4 pedigrees indicate which of the
following are possible modes of inheritance for the trait: (1) autosomal dominant
inheritance; (2) autosomal recessive inheritance; (3) mitochondrial inheritance; (4) Xlinked recessive inheritance; (5) X-linked dominant inheritance. Note: more than one
mode of inheritance may be possible for a given pedigree. Assume complete
penetrance and no heteroplasmy.
Pedigree 1 Pedigree 2 Pedigree 3 Pedigree 4 MCB 10 Problem Set 1 (15 Points Total) Fa 2016 Bambam and his father Fred both have two single locus autosomal dominant disorders:
epsilon sclerosis and gamma dystrophy. The genes that cause the two disorders are
located 7 cM apart on chromosome 12. Bambam’s mother Wilma is healthy (has neither
disorder). Bambam marries Pebbles who is healthy (has neither disorder).
Question 5 (2 Points): If Bambam and Pebbles have a child, what is the probability that
the child has both epsilon sclerosis and gamma dystrophy? Question 6 (2 Points): If Bambam and Pebbles have a child, what is the probability that
the child suffers from epsilon sclerosis but not gamma dystrophy? MCB 10 Problem Set 1 (15 Points Total) Fa 2016 In a study of 653 family trios (each consisting of a mother, father and child) the following
numbers of recombinant chromosomes (among the 1306 chromosomes found in the
children) were observed for two linked autosomal markers:
mother recombinant
31 father recombinant
48 Question 7 (1 Point): estimate the fraction of recombinants Question 8 (1 Point): what is the distance between markers in units of centiMorgans
(cM)? MCB 10 Problem Set 1 (15 Points Total) Fa 2016 Suppose that pattern baldness is caused by a single autosomal gene mutation that has
a dominant effect in males (either one or two copies of the mutation cause pattern
baldness) and a recessive effect in females (two copies of the mutation cause pattern
baldness). A second gene on a different autosomal chromosome affects hair color with
a recessive mutation that results in light hair instead of dark hair. Mary has pattern
baldness and light hair. Mary marries John who has no pattern baldness and dark hair.
John’s mother has light hair.
Question 9 (2 Points): If a son is born to the couple what is the probability that he has
pattern baldness and light hair? Question 10 (2 Points): If a son is born to the couple what is the probability that he has
no pattern baldness and dark hair? Question 11 (1 Points): If a daughter is born to the couple what is the probability that
she has no pattern baldness and dark hair?
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