12 Jun First step for DNA origami is to obtain the largest source
Question
First step for DNA origami is to obtain the largest source of single stranded DNA to make a template structure. M13mp18 bacteriophage genome (you can obtain the sequence from the genomic database online) with 7249 nucleotides has been commonly used for DNA origami designs. Using this same DNA source, design the largest possible square that is highly stable.
1. Estimate the size of the largest possible square that you can make using this DNA (M13mp18: )
2. Describe your design in detail and justify how you will achieve this structure. Write down the first three staple DNA sequences
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