12 Jun If there is a mutation in the sequence approximately
Question
Dr. Verybad has discovered a new neurodegenerative disease (Verybad disease, VBD).
The disease starts as headaches and muscle weakness and progresses to cognitive
impairment, loss of muscle control, and death. The cause of the disease is currently
unknown and there is no treatment. Dr. Verybad has a hypothesis that this is the result of
a mutation in a gene located on the X chromosome called Don’t Touch This gene 1
(Dtt1). Dr. Verybad wants to sequence the gene to determine if there is a mutation in Dtt1
responsible for the pathogenesis of VBD.
1) If the defect is in Dtt1, what do you predict would be the male to female incidence
of VBD and why? (10 points)
2) If there is a mutation in the sequence approximately 250 base-pairs upstream of
the transcription start sight, what might this mutation be affecting? Propose 1
experiment to investigate this possibility. Explain the protocol, controls, and
expected results. (10 points)
3) If there is a mutation that falls within an intron close to an exon junction, what
might this mutation be affecting? Propose 1 experiment to investigate this
possibility. Explain the protocol, controls, and expected results. (10 points)
4) If there is a mutation within an exon, what might this mutation be affecting?
Propose 1 experiment to investigate this possibility. Explain the protocol,
controls, and expected results. (10 points)
5) If there is a mutation in the 3’ Untranslated region (3’ UTR), what might this
mutation be affecting? Propose 1 experiment to investigate this possibility.
Explain the protocol, controls, and expected results. (10 points)
6) After sequencing the Dtt1 gene, Dr. Verybad found no changes in the gene
sequence. However, he has found that the protein forms aggregates within the
cells that results in plaque formation, neuronal loss, and a spongy look to the brain
tissue. What might the cause of this disease (5 points extra credit, up to a total of
50)
Our website has a team of professional writers who can help you write any of your homework. They will write your papers from scratch. We also have a team of editors just to make sure all papers are of HIGH QUALITY & PLAGIARISM FREE. To make an Order you only need to click Ask A Question and we will direct you to our Order Page at WriteDemy. Then fill Our Order Form with all your assignment instructions. Select your deadline and pay for your paper. You will get it few hours before your set deadline.
Fill in all the assignment paper details that are required in the order form with the standard information being the page count, deadline, academic level and type of paper. It is advisable to have this information at hand so that you can quickly fill in the necessary information needed in the form for the essay writer to be immediately assigned to your writing project. Make payment for the custom essay order to enable us to assign a suitable writer to your order. Payments are made through Paypal on a secured billing page. Finally, sit back and relax.
About Writedemy
We are a professional paper writing website. If you have searched a question and bumped into our website just know you are in the right place to get help in your coursework. We offer HIGH QUALITY & PLAGIARISM FREE Papers.
How It Works
To make an Order you only need to click on “Order Now” and we will direct you to our Order Page. Fill Our Order Form with all your assignment instructions. Select your deadline and pay for your paper. You will get it few hours before your set deadline.
Are there Discounts?
All new clients are eligible for 20% off in their first Order. Our payment method is safe and secure.