12 Jun You have been asked to design a virus that causes cancer
Question
uestion Completion Status:
Question 1
1.
All known human cancers have been demonstrated to be caused by viruses
Answer
True
False
2 points
Question 2
1.
Match the following cancers with the virus that has been demonstrated to cause the malignancy.
Answer
Answer
Hepatocellular
A
Carcinoma Human Papilloma Virus
.
Read Answer Items
B.
for Question 2 Hepatitis
C. HTLV-1
C Virus
Cervical
D
Carcinoma Epstein Barr Virus
.
Read Answer Items
for QuestionE. Human
2
Herpes Virus 8
Burkitt’s
Lymphoma
Read Answer Items
for Question 2
Kaposi’s
Sarcoma
Read Answer Items
for Question 2
Adult T-cell
Leukemia
Read Answer Items
for Question 2
3 points
Question 3
1.
You have been asked to design a virus that causes cancer in humans. Which of the following
cellular functions would this virus have to possess to cause a tumor (select all that apply)?
Answer
A Promote entry into cell cycle
.
B. Inhibit Tissue Specific Cell Adhesion
C. Inhibit
activity of cellular telomerase
D Inhibit Apoptosis
.
E. Promote cell cycle
arrest
F.
G
.
Enhance apoptosis
Enhance activity of cellular telomerase
3 points
Question 4
1.
To cause cancer, a virus must possess an oncogene
Answer
True
False
2 points
Question 5
1.
The Large T Antigen of the SV40 virus transforms cells by which mechanism below (select
one)?
Answer
A Causes release of E2F by interfering with E2F/Retinoblastoma
.
B. Enhances affinity of E2F for Retinoblastoma protein
C. Activation
interaction
of src kinase
D Induces severe inflammation and tissue
.
E. Mimics normal cellular growth factor
damage
2 points
Question 6
1.
Which of the following are mechanisms a virus could utilize to transform cells and induce a
tumor (select all that apply)?
Answer
A Viral
.
B. Viral
protein stimulates phosphorylation of Retinoblastoma protein
protein prolongs half-life of cellular p53 protein
produces a constitutively active growth factor receptor
Virus integrates within and inactivates src kinase
C. Virus
D
.
E. Virus
contains a mutant form of cellular src.
2 points
Question 7
1.
The Human Papilloma Virus E6 protein promotes tumor formation by which of the following
mechanisms (select one)?
Answer
A Stablizes cellular p53 protein
.
B. Induces chronic inflammation
C. Promotes
Ubiquitination of p53
D Mimics cellular growth factor
.
E. Dephosphorylates cellular src
2 points
Question 8
1.
A non-transducing retrovirus induces tumor formation by (select one)?
Answer
A Activates expression of tumor supressor gene
.
B. Represses activation of cellular proto-oncogene
C. Virus
integrates near proto-oncogene and increases its expression
that enhances cellular signaling
D Virus carries an ocogene
.
E. Activating apoptosis
2 points
Question 9
1.
Explain in 5-6 sentences why many viruses that cause cancer establish a latent infection in their
human host.
Answer
Press Tab to enter the content editor. For the toolbar, press ALT+F10 (PC) or ALT+FN+F10 (Mac).
Path: p
Words:0
2 points
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