13 Jun A new drug to treat ulcers of the stomach has a critical amino group
Question
Answer the following questions
A new drug to treat ulcers of the stomach has a critical amino group and a carboxyl group with pKa values of ~9 and ~4. In order to be active, both groups need to be in their acid (HA) form. Would this drug likely be effective if given orally? (The typical pH of the stomach is ~2.)A 3-year-old child was brought to the hospital with a cough, respiratory distress, and cyanosis (bluish skin due to deoxygenated hemoglobin). Physical examination suggested a lower respiratory tract infection. Other laboratory data available: p02 29, pCO2 75, pH 7.1. What is plasma bicarbonate concentration given pKa 6.1 for CO2-HCO3 buffer?
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