15 Jun Identify whether or not each of the following structures, sequences, or molecules
Question
Identify whether or not each of the following structures, sequences, or molecules would play a direct role in the production and localization of a secreted protein. If an item would play a role, select its checkbox. If the item would not play a role, leave its checkbox unchecked.
Choices: True,False. Select all that are True.
NLS
SRP
MPP
Signal peptidase
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Which one of the following statements comparing the targeting of a mitochondrial matrix protein to the targeting of a protein to the ER is correct?
Proteins destined for either compartment are likely to retain their amino terminal targeting signals.
Insertion of proteins into both compartments takes advantage of an energy source in the form of an electrochemical gradient.
The same signal can be used to direct a protein to either compartment, as long as the appropriate receptor recognizes the signal.
Proteins translocated into either compartment have an equal chance of ultimately being localized to the outside of the cell.
Proteins destined for either compartment are inserted into their respective compartments in an unfolded state.
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Which one of the following statements about translation at the ER membrane is correct?
BiP cleaves the signal peptide as the protein emerges into the lumen of the ER.
SRP releases the signal peptide and dissociates from the protein/ribosome complex after it docks with its receptor.
A folded protein can enter the ER as long as SRP targets it there.
Proteins that are targeted for the RER are completely translated at an ER-bound ribosome.
Targeting signals are always cleaved off of proteins directed to the ER
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Which of the following statements about signal recognition particle (SRP) is incorrect?
SRP binds directly but reversibly to a newly synthesized protein.
SRP possesses peptidase activity.
SRP binds directly but reversibly to a receptor molecule.
When SRP binds to its receptor, it triggers the opening of an ER translocon.
SRP binds directly but reversibly to a ribosome.
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Which one of the following statements about protein modification in the ER is incorrect?
Virtually all proteins that get translated into the lumen of the ER undergo N-linked glycosylation.
Lipid-linked proteins made in the ER will never face the cytoplasm.
Lipid-linked proteins synthesized in the ER are exposed on the cell surface.
Lipid-linked proteins are attached to the membrane via hydrophobic interactions between nonpolar amino acid residues.
BiP molecules as well as enzymes that catalyze disulfide bond formation perform their functions exclusively in the lumen of the ER.
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Order the following events, from earliest in the process to latest in the process, of a protein with an amino-terminal signal peptide being translated and folded in the ER lumen.
1 2 3 4 5 6 7 The signal peptide gets removed by signal peptidase
1 2 3 4 5 6 7 The translocon opens and the ribosome resumes translation
1 2 3 4 5 6 7 SRP binds to signal peptide and translation is halted
1 2 3 4 5 6 7 Signal peptide emerges from ribosome
1 2 3 4 5 6 7 SRP docks on the SRP receptor and the ribosome is lined up over the translocon
1 2 3 4 5 6 7 The SRP and ribosome are moved to the RER
1 2 3 4 5 6 7 The protein is bound by BiP and is correctly folded
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