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WHAT TYPES OF STUDIES WOULD YOU WANT TO EXCLUDE?

WHAT TYPES OF STUDIES WOULD YOU WANT TO EXCLUDE?

Managerial Epidemiology: What is the cost-effectiveness analysis and what is it used for in healthcare and public health? Provide an example study.
2. Qualitative, Quantitative (Cause-Effect): You are the Chief Operating Officer of a hospital. The Human Resources Director reports to you. Two of your valued Directors have a random drug screening for controlled substances with a group of hospital cohorts, and the result comes up as positive for heroine. Your experience with epidemiology and your understanding of cause-effect makes you skeptical of these general screening results. You request that the specimens be sent out to a specialty lab for confirmatory testing with gas chromatography specific for heroine. The results of the confirmatory testing show that both Directors are negative (0 mg/dl) for all control substances, including heroine. A further investigation revealed that both Directors attended a morning meeting the day of the random test and had eaten poppy seed muffins. You do research and find that poppy seed muffins produce a byproduct in the body that mimics opiates/heroine in a screening.
Discuss why these results occurred , i.e., the two very different results between a screening, and the confirmatory test in terms of a) qualitative and b) quantitative testing, c) specificity, d) reliability.
(Points : 10)
3. Research Methods: Why is the randomized clinical trial (RCT) research considered the “gold standard” in clinical epidemiology research? What is an IRB and why is it requirement when performing research with human beings? (Points : 10)
4. Decision Making: Clinical epidemiology research should be based on empirical evident. Define empirical evidence and what it means in decision making in both private and public health decision making in regard to interventions, i.e., the implementation of medical testing, processes or public health programs. (Points : 10)
5. Risk Factor Research: Why is the Framingham Heart Study a pivotal research program in healthcare today? What are some of the milestones the study has given to clinical epidemiology? (Points : 10)
6. NOTE: Essay Question is in 2 parts. This is Part 1 to be completed and then go , to Part 2 and complete it.

Case #2 of 2: (50 pts) Cost/Benefit literature review for vaginal birth after cesarean (VBAC)

A client had a cesarean delivery in a hospital setting for breech presentation with her first pregnancy. She is pregnant again and after exploring her delivery options, has decided she wants to attempt a vaginal birth after cesarean (VBAC). She has had an uncomplicated pregnancy this time and the fetus is not breech. The same OB-GYN will be assisting in her delivery. The OB-GYN performs a systematic review of the literature to assess the benefits and harms of VBAC versus repeat cesarean delivery.

Part 1 of 2: Researching Empirical Evidence

1. What kinds and sources of data does the OB-GYN need to review in order to make a rational clinical planning decision?
2. Which types of studies available on this topic would be the most useful in clinical decision making?
3. What types of studies would you want to exclude?
4. Why would there be a lack of randomized clinical trials (RCT’s) available to address this clinical question?(Points : 20)
7. NOTE: This is Part 2 of the final essay question: The last essay question requires you to do a 2×2 table in addition to calculations. The tables may be done by copying the table from the question directly into your answer and then filling the table out.

Case: Calculating Odds Ratio
In planning for her delivery, the client reads about birthing centers and asks the midwife if it is safe to have a VBAC in a freestanding birthing center. The midwife reviews the data from national studies of VBACs in birthing centers compared to VBACs in hospital settings and obtains the following statistics to aid her in clinical decision making:

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