Note: You can use ribbon, pipe cleaners, or similar materials in your model.

Note: Take a picture of your completed model as evidence that you created it. You can include the picture as part of your presentation or report, or you can upload it in Taskstream as a separate attachment.

2. Explain three major differences between the oxygenated and deoxygenated states of hemoglobin.

3. Explain how pH impacts the binding and release of oxygen by hemoglobin.

a. Create an original graph that demonstrates the relationship between hemoglobins oxygen binding and oxygen concentration at different pH levels.

4. Create an original diagram that compares the biochemical (protein) structure of hemoglobin to myoglobin.

a. Label each of the following components in the diagram from part A4 to show the comparison:

• subunits

• heme groups

• iron atoms

• oxygen molecules

Note: Take a picture of your completed diagrams as evidence that you created it. You can include the picture as part of your presentation or report, or you can upload it in TaskStream as a separate attachment.

B. Demonstrate your understanding of sickle cell anemia by doing the following:

1. Create an original diagram that demonstrates the molecular difference (amino acid change) between normal and sickle forms of hemoglobin.

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Note: Take a picture of your completed diagram as evidence that you created it. You can include the picture as part of your presentation or report, or you can upload it in Taskstream as a separate attachment.

2. Create an original diagram that demonstrates the difference between normal and sickle red blood cells at the cellular level.

Note: Take a picture of your completed diagram. You can include the picture as part of your presentation or report, or you can upload it in TaskStream as a separate attachment.

3. Compare how diseased cells differ from normal red blood cells in their capacity to transport and deliver oxygen.

4. Explain the molecular inheritance of sickle cell anemia by doing the following:

a. Identify the type of inheritance seen in sickle cell anemia.

b. Describe the outcomes for the offspring of two carrier parents (genotype and phenotype and percentages of each).

c. Create a diagram, or series of simple diagrams, that demonstrates of how sickle cell genes are inherited (e.g., pedigree charts, Punnett squares).

Note: Take a picture of your completed diagram. You can include the picture as part of your presentation or report, or you can upload it in TaskStream as a separate attachment.

C. When you use sources, include all in-text citations and references in APA format.

Note: For definitions of terms commonly used in the rubric, see the attached Rubric Terms.

Note: When using sources to support ideas and elements in an assessment, the submission MUST include APA formatted in-text citations with a corresponding reference list for any direct quotes or paraphrasing. It is not necessary to list sources that were consulted if they have not been quoted or paraphrased in the text of the assessment.

Note: No more than a combined total of 30% of a submission can be directly quoted or closely paraphrased from sources, even if cited correctly. For tips on using APA style, please refer to the APA Handout web link included in the General Instructions section.

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