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Describe the following genetic changes at the molecular level

Describe the following genetic changes at the molecular level

Question
Spring 16 Chapters 16&17
1. Please describe the following genetic changes at the molecular
level and explain whether or not such changes may affect gene
dosage, expression level or gene structures (14 pts).
Point mutation Euploid Aneuploid Deletion Duplication Inversion
Translocation
2. Describe the two types of known chromosomal changes
underlying Down syndrome? Explain which type is genetic
(transmitted in families), while the other one is sporadic (no family
history), and why? (6 pts)
3. Point mutations have less deleterious effect when comparing to
large-scale chromosomal changes (e.g. changes in the ploidy of an
organism or chromosomal deletion, duplication, inversion and
translocation). Do you think the above statement is correct? Why
or why not? (3 pts)
4. Please list and describe six DNA repair mechanisms (pathways).
Explain which ones occur only in dividing cells. (7 pts)

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