01 Jul Genetic Lab
Question Description
For the following question, you are encouraged to refer to the American Pregnancy Association article, “In Vitro Fertilization: IVF,” and the Multimedia presentation, “The Marvel of Prenatal Development,” listed in the Resources.
What are the similarities and differences between natural conception and in-vitro fertilization (IVF)?
GENETICS
For the following questions, you are encouraged to refer to the following materials listed in the Resources: the “Human Genetics” chapter in the Ahluwalia e-book; the “Genes in Pedigree” chapter in the Strachan and Read Internet resource; the “Human Pedigree Analysis” chapter in the Griffiths, Gelbart, Miller, and Lewontin Internet resource; and the “Genetic Counseling” Internet article from the Nemours Foundation.
How are chromosomes passed down from parents to children? Why is the haploid number of chromosomes from the egg and the sperm important in order for a child to have the correct number of chromosomes? What could happen if a child has less or more than 46 chromosomes?
How are Punnett squares useful in determining how genes are passed down from each parent to a child?
What is a family pedigree? How are family pedigrees used to determine the chances of familial genes being passed down to offspring? How could a genetic counselor use a family pedigree to advise parents about the chances of a child inheriting familial genes?
Scenario One – Our patient seeks genetic counseling
Kayla has a family history of Duchenne muscular dystrophy (DMD), which is a sex-linked trait. The patient wishes to know her risk of having an affected child. Her grandmother was a known carrier. DMD is an inherited disorder that involves progressive muscle weakness. It affects approximately 1 in 3500 male births worldwide and is inherited in an X-linked recessive pattern.Click here to learn more about DMDThe following pedigree was drawn up by the genetic counselor. Our patient, Kayla, is #13.
What are the relationships between:
1 and 2
1 and 5
1 and 10
6 and 7
4 and 5
5 and 8
8 and 10
1 and 3
What are the chances her mother was a carrier?
What are the chances our patient is a carrier?
What are the chances she passes the syndrome to a male child?
Testing would establish her status as either a carrier or a noncarrier.
If she is a carrier what are the chance of her having an affected child?
If she is not a carrier what are the chance of her having an affected child?
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