23 Jul WHY IS ONE AFFECTED AND NOT THE OTHER?
HIV the virus that causes AIDS depends on an enzyme called reverse transcriptase in order to multi Show more HIV the virus that causes AIDS depends on an enzyme called reverse transcriptase in order to multiply. Reverse transcriptase reads a molecule of RNA and creastes a molecule of DNA from it. A molecule of azidothymidine AZT the first drug approved to treat AIDS has a shape very similar to that of thymidine and is known to inhibit reverse transcriptase. This is more of a thinking question. a. Base on its shape propose a model for how AZT is able to inhibit HIV reverse transcriptase. b. In normal uninfected cells would AZT directly interfere with DNA replication or RNA transcription? Explain your response. Why is one affected and not the other? c. What is the major serious side affect (not necessarily the most common) from this drug (six letters starts and ends with an A)? Why would the mechanism described above cause this? Show less
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