11 Jun ASU BIO 182 – A variety of mutations are listed
Question
Exam 4: Extra Credit. For full credit answer BOTH #1 and #2 below.
1) A variety of mutations are listed below. FOR EACH: a) give a complete definition in your own words, b) discuss the “downstream” consequences of each type of mutation during gene expression (what effects on transcription/translation), and c) provide a “real-life” example of each (perhaps a disease caused by this type of mutation).
Point mutations (include discussion of the difference between transitions and transversions)
Missense mutations
Nonsense mutations
Silent mutations
Splice-site mutations
Insertion/Deletion mutations
2) Fully discuss the EVOLUTIONARY SIGNIFICANCE of introns. For example (but not limited to): What is their distribution in the tree of life? What’s the significance of their distribution in the tree of life? Discuss several ways they can introduce new variants into populations. What is alternative splicing?
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