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BCHM 551 – Why will a patient with Systemic Carnitine

BCHM 551 – Why will a patient with Systemic Carnitine

Question
Why will a patient with Systemic Carnitine deficiency experience repeated episodes of hypoglycemia?
Why would there be steatosis (lipid accumulation) in th liver of a patient with Systemic Carnitine deficiency? Why will skeletal muscle carnitine content remain below normal despite high-dose carnitine therapy in this patient?
Give at least 3 possible explanations for a false-negative result in a patient with G6PD deficiency?
Distinguish in biochemical detail between peroxisomal ?-oxidation of fatty acids and mitochondrial ?-oxidation of fatty acids.
Distinguish in biochemical detail between ?-oxidation of saturated and unsaturated fatty acids.

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