13 Jun How do changes in ventilation rate, cardiac output
Question
Ventilation-Perfusion Assignment Questions
1. How do changes in ventilation rate, cardiac output, and dead space ventilation
affect alveolar PO2 and pulmonary venous PO2? Do these three factors have an
additive effect towards increasing or decreasing total oxygen delivery to tissues.
Explain.
Matlab files Vsensim and fdeadsens can be used as a guide for Qn #1
2. How can a change in mixed venous PO2 affect alveolar PO2 and total oxygen
delivery to tissues?
3. Consider three different metabolic rates for an average person, viz., resting, active,
maximal activity. How should the ventilation and perfusion rates change under
each of these circumstances in order to ensure sufficient delivery of oxygen to the
tissues? Would these rates also maintain sufficient saturation of blood in the
pulmonary capillaries for each activity?
4. What happens to total oxygen delivery to tissues if there is a decrease in dead
space ventilation? What other factor(s) could affect the oxygen delivery?
5. The Matlab file VQ3levsimrun systematically varies the ventilation and perfusion
rates in the different lung segments. Explain what happens to the partial pressure
of oxygen in the alveoli and the concentration of oxygen in the alveoli for the
different lung segments in each case. Explain how the oxygen concentrations at
the left atrium (and in the systemic circuit) are affected by the variation in alveoli
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