23 Jul HOW MANY SUBSTITUTIONS OCCUR AT NON SYNONYMOUS SITES?
To investigate if the Aspm gene has been affected by positive selection during the divergence of hum Show more To investigate if the Aspm gene has been affected by positive selection during the divergence of human and chimp we focus on two aligned sequences from the Aspm gene. Human: CGT GGC GCA CTT GTA Chimp: CGT CGT CCA CTT GTA (1) Use the genetic code to identify the sites that are nonsynonymous. How many nonsynonymous sites did you find? How many synonymous sites are there then? (2) How many substitutions (differences between sequences) have occurred between human and chimp? How many substitutions occur at non synonymous sites? How many substitutions occur at synonymous sites? (3) Using your results in (1) and (2) calculate dN dS and the ratio dN/dS. What can you conclude and why? Show less
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