10 Jun Level Compared to Normal (High, Normal, or Low)
Question
The ME’s report also has a note at the end. She suspects poisoning based on the below results.
Metabolite
Level Compared to Normal (High, Normal, or Low)
Oxygen
High
NADH
High
NAD+
Low
Pyruvate
Normal
Glucose
Normal
Acetyl CoA
Normal
ATP
Low
ADP
High
1. What is the role of each of the above metabolites in cellular respiration?
2. Which of the above are abnormal? Which are normal?
3. Based on your answers to the first two questions, what part of cellular respiration do you believe was interrupted?
Part IV: Test Results
The ME received results for three poisons, and one came back positive: cyanide, a potent inhibitor of cellular respiration.
1. What is the mechanism of action of cyanide? Focus on the enzyme it inhibits, the type of inhibition, and the normal role of the enzyme in cellular respiration.
2. Explain how Meleea died of asphyxiation when her oxygen levels are high.
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