25 Jun Medical practioners who used hydroxyurea as a treatment for sickle cell
Question
b. Medical practioners who used hydroxyurea as a treatment for sickle cell anemia noted that theirpatients seemed to benefit from the administration of the drug long before the synthesis of fetalhemoglobin had time to take effect. It has recently been determined that hydroxyurea can reactdirectly with the iron ion of oxy- and deoxyHb to form iron nitrosyl hemoglobin (HbNO). Whywould this be of benefit to the sickle-cell anemic patient?
c. In addition, hydroxyurea has been shown to produce NO directly, in less than an hour afterhydroxyurea administration. It’s also possible that HbNO could produce free NO, either directlyor indirectly. NO is an mportant second messenger which, even in nanomolar amounts,stimulates vasodilation. How could production of NO help the sickle-cell anemic patient?
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