26 Jun Most therapeutic monoclonal antibodies being
Question
BS3046 Timed Essay Titles April 2014
The essay will be written in class on the 22nd April 2-3 (LT.03).
You can choose which title you would like to do as either essay may be written in class.
The essay will be written under examination conditions. ie. you will not be allowed access to notes. You will get 45mins to write the essay.
Note that we will expect you to research your answer using relevant scientific resources. You will not be able to fully answer the question based on the lecture notes alone.
1. Most therapeutic monoclonal antibodies being used in the clinic today are fully human. Describe in detail the methods by which a human monoclonal antibody may be generated and why these reagents are more effective for use in the clinic than their mouse counterparts (50%).
The fully human MoAb, Ofatumumab is currently being used in clinical trials for the treatment of B cell lymphoma. With reference to at least two clinical trials discuss the advantages and disadvantages of using this MoAb in the treatment of B cell lymphoma. (50%).
2. In an attempt to develop a new vaccine against an expecially dangerous virus, you have immunised groups of mice with DNA coding for a viral antigen. Discuss the experiments you would perform in order to demonstrate the activation of a specific immune response and the efficacy of your vaccine.
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