26 Jun Nucleic acid aptamers are an emerging class of affinity ligands
Question
Nucleic acid aptamers are an emerging class of affinity ligands that can bind to their targets with very high affinities and specificities. Moreover, they can be synthesized chemically. Therefore, aptamers have attracted great attention in a variety of biological and biomedical fields such as cancer diagnosis, drug delivery and regenerative medicine. For instance, researchers have integrated aptamers into microfluidic systems to make artificial tissues to capture circulating tumor cells from a patient’s blood for in vitro diagnosis. The ability to enumerate and characterize circulating tumor cells is expected to open a new avenue for cancer diagnosis as well as the detection of other types of cells in different biological and biomedical systems. However, the identification of aptamers faces many challenges. For instance, if our purpose is to select an aptamer that plays a role at the solution-cell interface, we will not want aptamer uptake to occur. To avoid cellular uptake, researchers often have to do aptamer discovery in the ice bath. One leading research group identified an aptamer that can bind to human Burkitt’s lymphoma cells in the ice bath. The sequence of this aptamer is: TCACACTTAAAAAAAAAAAAAAACACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCCGGTG However, researchers found that this aptamer worked well in the ice bath but did not work when it was delivered in the body. Please analyze what the potential problem is and why it leads to the failure in the body. 1) to simply the problem, compare the structures and gibbs free energy values of the aptamer at 0 and 37 degree Celsius. 2) please also examine how the concentration of magnesium affects gibbs free energy by comparing three concentrations including 0, 2 and 5 mM. The concentration of Na+ is 138 mM.)
Our website has a team of professional writers who can help you write any of your homework. They will write your papers from scratch. We also have a team of editors just to make sure all papers are of HIGH QUALITY & PLAGIARISM FREE. To make an Order you only need to click Ask A Question and we will direct you to our Order Page at WriteDemy. Then fill Our Order Form with all your assignment instructions. Select your deadline and pay for your paper. You will get it few hours before your set deadline.
Fill in all the assignment paper details that are required in the order form with the standard information being the page count, deadline, academic level and type of paper. It is advisable to have this information at hand so that you can quickly fill in the necessary information needed in the form for the essay writer to be immediately assigned to your writing project. Make payment for the custom essay order to enable us to assign a suitable writer to your order. Payments are made through Paypal on a secured billing page. Finally, sit back and relax.
About Writedemy
We are a professional paper writing website. If you have searched a question and bumped into our website just know you are in the right place to get help in your coursework. We offer HIGH QUALITY & PLAGIARISM FREE Papers.
How It Works
To make an Order you only need to click on “Order Now” and we will direct you to our Order Page. Fill Our Order Form with all your assignment instructions. Select your deadline and pay for your paper. You will get it few hours before your set deadline.
Are there Discounts?
All new clients are eligible for 20% off in their first Order. Our payment method is safe and secure.