01 May Q1 : Write notes on three of the following: • Physiological mechanisms
Q1 : Write notes on three of the following: • Physiological mechanisms for the maintenance of serum calcium • The pathophysiological features of Metabolic Syndrome • The Acute Phase Response in relation to Serum Protein Electrophoresis • Analysis of HDL-Cholesterol • The role of B-type natriuertic peptide (BNP) measurement in the diagnosis and management of cardiac failure • The cause, consequences and diagnosis of Gestational Diabetes Q2 : List the causes of pre-hepatic, hepatic and post-hepatic jaundice and describe the typical Liver Function Tests (Alb, TProt, TBili, ALT, ALP and gGT) results seen in these conditions? Q3 : Describe the physiological basis of the development of diabetic ketoacidosis and outline the typical biochemistry results seen in this condition? Q4 : Various markers related to the ‘acute phase response’ have been found to be useful as cardiac risk factors. Discuss this statement in light of the role of inflammation in atherosclerosis? Q5 :Define and describe the various types of jaundice. How could you determine the likely cause of jaundice in these situations? Q6 : Outline the clinical significance and limitations of ? Glutammyl Transferase activity measurement in the assessment of liver function ? Q7 : Compare and contrast the use of CKMB activity and cTroponin as markers of myocardial infarction ? Q8 : Outline the features of the Metabolic Syndrome and describe the biochemical parameters that change in this condition ? Q9 : Describe the metabolism of cholesterol and triglyceride noting in particular the role that the liver plays in maintaining levels of cholesterol. In your answer define the structure and roles of the individual lipoproteins.? Q10 Describe the predominant lipid abnormalities and classical clinical features found in familial hypercholesterolaemia. Outline the primary treatment regimens and how they act to influence lipid levels? Q11 In the diagnosis of CHD, what advantages over the measurement of LDL/HDL ratio are offered by measurement of Apo A1/Apo B ratio or Lipoprotein (a) concentration? Q12 : Outline the diagnostic utility and limitations of serum ferritin, transferrin and Total iron binding capacity (TIBC) as markers of iron deficiency? Q13 : Describe the social factors that are associated with iron deficiency in infants?
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