02 May The case consider Mr TY who has been diagnosed with of Stage 3B Hodgkin’s Lymphom
The case consider Mr TY who has been diagnosed with of Stage 3B Hodgkin’s Lymphoma
Doxorubicin is an anthracycline antibiotic with anti-tumour properties. It binds to the nucleic acids (both DNA and RNA) by specific intercalation of its planar anthracycline nucleus with the DNA double helix. It is given on days 1 and 15 of the Stamford V regime. This medication has known side effects on the myocardium and therefore ECGs are routinely done throughout the treatment cycle. Doxorubicin is given at 25mg/m2 as IV boulus
Why is cardiotoxicity associated w/ anthracyclines (e.g. doxorubicin, epirubicin, idarubicin)? Include overview of radical based processes.Ø
Main problem of anthracyclines is that they can cause cardiotoxicity. The major dose dependent toxicity is HF which is fatal. Prevention of cardiomyopathy can be done via dosage optimisation and combination chemoTx. There is reduced cardiotoxicity when antioxidants or iron chelators are administered also.ü
The mechanism involves free radical damage in the cardiac tissue. The low levels of free radical scavenging enzymes in the heart which offer protective mechanisms can be overpowered by radicals formed from anthracycline administration.ü
Redox properties of quinone functionality generates free radicals (hydroxylü & superoxide radicals) that have a central role in cardiotoxicity.
Superoxide radical reacts w/ cell membranes and damages the membranes of cancer cells.ü
Hydroxyl radical is one of the most destructive chemical species known. It alters calcium ion transport, causes DNA base oxidation, DNA strand cleavage, protein oxidation, thiol oxidation and lipid membrane oxidation.ü
this are some information about the drug and management if the drug cause cardiotoxicity.
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The purpose of the individual report is to enable you the opportunity to show that you have researched the primary
evidence to understand why certain treatment regimens are used in the treatment of various cancers. You therefore
must reference PRIMARY sources of evidence in this report. We would like you to structure your report with the
following sub-headings:
Introduction to the agent you have chosen to focus on
The place in therapy of this agent
Evidence base for the use of this agent including critical appraisal of this evidence
Patient related aspects of the use of this agent – this must be related to the patient in YOUR case not generic (i will add/upload the case )
The report will be marked in the following FOUR areas(please look at the attachment)
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