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There are many different kinds of harmful poisons

There are many different kinds of harmful poisons

Question
There are many different kinds of harmful poisons that interfere with metabolic functions. One such compound is 2,4-Dinitrophenol or DNP. This has been used in industry as a dye and wood preservative. It was even once used as a dieting aid back in the 1930’s due to it’s ability to increase metabolic rate.

The drug works by binding to H+ ions and then transporting them across a membrane. It is fat soluble so it can cross membranes freely and it takes H+ ions along with it. This makes it a metabolic uncoupler.

Based on what you know about metabolism and H+ gradients, what effect would DNP have on cells? Why would this cause metabolism to speed up so it could be used as a diet drug?

Grading Rubric:

6 points – Explained effect on the specific metabolic process involved

6 points – Described how this would speed up metabolism

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