12 Jun UC PHARMSCI 170 – How many chemical structures
Question
How many chemical structures are represented by the Markush structure
shown?
Question 2 of 7 0.7
From data provided in Bell, et al., which of the following compounds showed the highest selectivity for the IGFRK enzyme over the IRK enzyme?
A. 1
B. 2
C. 3
D. 4
E. 5
F. 6
G. 7
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Question 3 of 7 0.71 Points
From data provided in Bell, et al., which of the following compounds showed the highest potency for the IGFRK enzyme?
A. 1
B. 2
C. 3
D. 4
E. 5
F. 6
G. 7
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Question 4 of 7 0.71 Points
From data provided in Bell, et al., which of the following compounds showed the highest potency for the IRK enzyme?
A. 1
B. 2
C. 3
D. 4
E. 5
F. 6
G. 7
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Question 5 of 7 0.71 Points
The experimental data used to calculate an IC50 are typically which of the following?
A. Activity of an enzyme at different enzyme concentrations, in the presence of an inhibitor
B. Activity of an enzyme at different time points, in the presence of an inhibitor
C. Activity of an enzyme at different substrate concentrations, in the presence of an inhibitor
D. Activity of an enzyme at different inhibitor concentrations, in the presence of a substrate
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Question 6 of 7 0.71 Points
In planning a rat PK experiment, how much compound should you have, in order to determine standard PK parameters of a compound. Assume that the rats weigh 200g each, you draw blood at 6 time points, use 5 rats per group, and inject 10mg/kg iv into each rat.
A. 1ug
B. 10ug
C. 100ug
D. 1mg
E. 10mg
F. 100mg
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Question 7 of 7 0.71 Points
A 2g dose of kinetolol was administered to an 80kg healthy volunteer as an iv injection. Plasma concentrations of the drug were measured at various times after the drug administration, and area under the curve (AUC) was calculated to be 200 (mg hour)/L. The total Clearance of the drug is:
A. 10 L/hour
B. 0.01 hour/L
C. 0.01 L/hour
D. 10 hour/L
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