23 Jul WHAT ARE THE CORRESPONDING FREE-ENERGY CONTRIBUTIONS TO CHANNEL OPENING AT 25C?
. The ratio of open to closed forms of the acetylcholine receptor chan Show more Ligand-induced channel opening. The ratio of open to closed forms of the acetylcholine receptor channel containing zero one and two bound acetylcholine molecules is 510^-6 1.210^-3 and 14 respectively. (a) By what factor is the open-to-closed ratio increased by the binding of the first acetylcholine molecule? The second acetylcholine molecule? (b) What are the corresponding free-energy contributions to channel opening at 25C? (c) Can the allosteric transition be accounted for by the MWC concerted model (Section 7.2)? Show less
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