24 Jul WHAT DO THESE DATA INDICATE ABOUT THE CELLULAR REQUIREMENTS FOR VIRAL INFECTION IN DIFFERENT TISSUES?
To investigate the role of proteins p24 and p25 for viral replication in live mice transgenic mice Show more To investigate the role of proteins p24 and p25 for viral replication in live mice transgenic mice that lack genes for p24 or p25 are generated. A knockout system is used to selectively delete the genes in cells of either the liver or the lung. Wild type and knockout mice are infected with virus. After a 24hour incubation period mice are killed and lung and liver tissues are removed and examined for the presence (infected) or absence (normal) of virus using specific antibodies. What do these data indicate about the cellular requirements for viral infection in different tissues? Tissue Examined MouseLiverLung Wild type.infectedinfected Knockout of p24 in livernormal..infected Knockout of p24 in lunginfectedinfected Knockout of p25 in liverinfectedinfected Knockout of p25 in lunginfectednormal Show less
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