24 Jul WHICH OF THE FOLLOWING IS NOT CASUED BY A CHROMOSOMAL DELETION?
QUESTION 34 A mutation in the mitochondria is limited in its cellular effects primarily because Show more QUESTION 34 A mutation in the mitochondria is limited in its cellular effects primarily because a. there are so few genes carried by the mitochondria b. there is so much untranslated or junk DNA in the mitochondria c. the genes in the mitochondria are not critical for cellular function d. there are so many copies of mtDNA in each mitochondria e. mtDNA is only passed down from the mother 1 points QUESTION 35 All of the following are required for HIGH-level expression of the lac structural genes EXCEPT: a. RNA polymerase + sigma factor b. CAP-cAMP c. LacI bound to allolactose d. glucose 1 points QUESTION 36 A woman with facioscapulohumeral muscular dystrophy (FMD) an autosomal dominant trait is seeking advice on having children. FMD does not run in her family. Her husband who is 28 and normal has an uncle with Huntingtons disease (HD; autosomal dominant). His parents are normal and both are over 50. Symptoms of Huntingtons disease may appear from 12 to 65 years after birth; however all HD members of his fathers kindred developed signs during their thirties. HD and FMD are fully penetrant. What are the genetic risks for this couples children? a. 50% FMD 50% HD b. 100% FMD 0% HD c. 50% FMD 0% HD d. 50% FMD 25% HD e. 0% FMD 50% HD 1 points QUESTION 37 E. coli strains that are Hfr strains _______. a. possess an F factor that has integrated into the bacterial chromosome b. have a low frequency of recombination c. possess an F factor in the cytoplasm d. are susceptible to infection by a bacteriophage 1 points QUESTION 38 I have a spermatagonia cell (the cell that makes sperm) and it is undergoing meiosis. It has a non-disjunction event and of the 4 spermatids created two have 24 chromosomes and two have 22 chromosomes. What happened? a. A non-disjunction event in meiosis I b. A non-disjunction event in meiosis II c. A non-disjunction event in mitosis e. A mutation in the centromere f. A mutation in the sex chromsome 1 points QUESTION 39 An individual with a disease demonstrates a set phenotypic presentation let us say the inability to appreciate 80s music a most terrible affliction. Another individual with the same phenotypic presentation is discovered. When we sequence their genome we find that there are two distinct DNA sequences involved both differing from wt but they are located in the same gene in both individuals. This demonstrates a. Allelic heterogeneity b. Locus heterogeneity c. Pleitropy d. Penetrance e. Expressivity 1 points QUESTION 40 What is the most likely genetic consequence of a homozygous translocation? a. abnormal pairing of chromosomes duting meiosis b. gene duplications c. inviable gamete formation d. an alteration in the linkage relationship of genes e. formation of abnormal chromatids following crossing-over 1 points QUESTION 41 From your reading attenuation in trp gene regulation is accomplished by a. repressing the trp operons operator. b. reducing the cells permeability to the effector molecule tryptophan. c. blocking transcription initiation at the trp operons promoter. d. forming secondary mRNA structures in the leader region of the transcript. 1 points QUESTION 42 Which of the following explains why the lac operon is regulated by catabolite repression a positive control mechanism that is sensitive to the amount of glucose available to the cell? a. Catabolite repression allows the cell to choose glucose over lactose when both are available. b. Catabolite repression allows the cell to stockpile the enzymes needed for lactose metabolism. c. Catabolite repression inhibits synthesis of the lac repressor lacI until glucose is consumed. d. Catabolite repression allows the cell to store sugars for use later. 1 points QUESTION 43 I talked about a few specific diseases caused by chromosomal deletions. Which of the following is not casued by a chromosomal deletion? a. Cri-du-chat b. Prader-Willi c. Fragile X Syndrome 1 points QUESTION 44 Which of the following provides the BEST explanation for how a lacI S mutation carries out its function in a trans-dominant manner? a. The mutation affects the expression of genes located on another piece of DNA b. The mutation continues to affect cells for multiple generations. c. The mutation affects bacterial cells that do not carry the lacI S allele. d. The mutation affects upstream or downstream genes on the same chromosome. 1 points QUESTION 45 I mate an individual that is AaBbCcDd to another individual that is AaBbCcDd (Both heterozygotes for all 4 genes). What is the probability that a child they have is homozygous dominanat for all of these genes? a. 1/16 b. 1/64 c. 1/256 d. 1/8 e. 3/4 f. 1/2 1 points QUESTION 46 mtl polA and xyl are bacterial genes that can be transmitted using an Hfr strain. An interrupted mating experiment resulted in xyl transconjugants appearing at 7 minutes and reaching maximum level by 30 minutes. The mtl transconjugants appeared at 11 minutes and leveled off at 80% maximum by about 33 minutes while polA did not appear until 24 minutes and then only rose slowly to about 30%. Which of the following lists the gene order and direction of insertion correctly? a. mtl polA xyl ? b. xyl mtl polA ? c. polA mtl xyl ? d. mtl xyl polA ? 1 points QUESTION 47 Which of these is the most true of mtDNA? a. It is resistant to mutation. b. It is not wrapped around histones. c. It is only replicated during cellular meiosis. d. It is only replicated during S phase. e. It has large numbers of exons. 1 points QUESTION 48 Familial Downs creating an inherited form of a disease also caused by chromosome nondisjunction can be caused by a. Robertsonian translocations b. deletion of chromosome 21 c. Philadelphia chromosome d. dating NAU students e. inversion of centromeric DNA regions 1 points QUESTION 49 If two chiasmata occurr between two genes the resulting phenotype for this recombination would be a. parental. b. single recombinant. c. double recombinant. d. dominant. e. recessive. 1 points QUESTION 50 Fragile X syndrome is created by ______ at the end of the X chromosome. a. a non-disjunctional event b. a frame shift mutation c. a nonsense mutation d. a broken DNA strand e. a series of trinucleotide repeats 1 points QUESTION 51 The inducer of the lac operon is _______ whereas the repressor of the trp operon is _______. a. allolactose tryptophan b. tryptophan allolactose c. lactose arabinose d. galactose tryptophan 1 points QUESTION 52 An allele that exhibits incomplete dominance is usually haplosufficient. a. True b. False 1 points QUESTION 53 In the lac operon in E. coli a nonsense mutation in the _______ gene will result in a loss of ?-galactosidase activity in the cell. a. lacY b. lacZ c. lacI d. Both B and C are correct. 1 points QUESTION 54 An individual is composed of cells and these cells should all come from the zygote which was formed duting fertilization. Once in a while we will find that cells from two different regions of the body may contain cells from what must have been 2 different fertilization events meaning the genotypes for these regions are distinctly different. This is an example of a. mosaicism b. chimerism c. pleitropy d. non-disjunction e. X-linked dominance 1 points QUESTION 55 A testcross of trihybrid Drosophila produced the following phenotypes and number of offspring. A table showing phenotype and the number of offspring with each phenotype is below. A plus sign is used for wild-type phenotype; a letter indicates the mutant phenotype for that gene. +++ 669 abc 653 ++c 121 ab+ 139 +b+ 2280 a+c 2215 +bc 3 a++ 2 Which gene pair is closer together; i.e. there are fewer map units between them? a. a > b b. b > c c. a > c d. a > b and b > c are the same length e. a > c and b > c are the same length f. Cannot be determined Show less
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