10 Jun Which of the following statements about the vitamin D receptor
Question
68. Which of the following statements about the vitamin D receptor is not true:
A. Binds DNA as a heterodimer with RXR.
B. Has activity level that relates to sun exposure.
C. Binds an inverted repeat response element.
D. Is not located in the cytoplasm in its unliganded state.
E. Has a high affinity for 1,25-dihydroxyvitamin D.
69. You are working on your PhD in cancer research and find that a breast tumour cell sample expresses what you believe to be a mutated form of estrogen receptor (ER). You clone and sequence the tumour ER and then express it to make protein? You run a gel mobility shift assay with the radiolabelled estrogen response element (ERE), combined with mutant ER and normal ER proteins and see that you have 1 small band corresponding to the naked DNA probe at the bottom of the gel and the protein-DNA complex(es) at the top of the gel. You conclude from the gel that the mutant ER is a truncated fom of protein because the complexes at the top of the gel comprise:
A. no bands
B. one band
C. 2 bands
D. 3 bands
E. a smear
70. You take the mutant ER protein (question above) and determine whether it can bind to radiolabelled estrogen. It cannot. Therefore it is likely that the truncation of the protein is associated with the:
A. Carboxy-terminal end of the protein.
B. Amino-terminal end of the protein
. C. N-terminus of the co-activator protein.
D. DNA-binding region of the protein.
E. HSP70 protein complex.
71. Which statement is not true concerning retinoic acid receptors:
A. The binding of retinoic acid causes a conformational change in the ligand binding domain of the receptor that decreases binding affinity for transcription corepressors.
B. The binding of retinoic acid causes a conformational change in the ligand binding domain of the receptor that increases binding affinity for transcription coactivators.
C. Involves helix-12 of the ligand binding domain.
D. Is not located in the cytoplasm in its unliganded state.
E. Has a high affinity for 1 ,25-dihydroxyvitamin D.
72. RU-486 is an antagonist of the progesterone receptor. It most likely acts by:
A. Interfering with progesterone uptake into the cell.
B. Causing skin irritation
C. It works like progesterone but it does not bind to the progesterone receptor.
D. It binds the progesterone receptor but doesn’t permit it to transcriptionally activate.
E. It competes with the ER for DNA binding.
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